6BIT

SIRPalpha antibody complex

Summary for 6BIT

• Entry DOI: 10.2210/pdb6bit/pdb
• Descriptor: KWAR23 Fab heavy chain, KWAR23 Fab light chain, Tyrosine-protein phosphatase non-receptor type substrate 1, ... (4 entities in total)
• Functional Keywords: macrophage, neutrophil, phagocytosis, myeloid, immune checkpoint, cd47, sirp, cancer immunotherapy, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 117590.84

Authors

Ring, N.G.,Herndler-Brandstetter, D.,Weiskopf, K.,Shan, L.,Volkmer, J.P.,George, B.M.,Lietzenmayer, M.,McKenna, K.M.,Naik, T.J.,McCarty, A.,Zheng, Y.,Ring, A.M.,Flavell, R.A.,Weissman, I.L. (deposition date: 2017-11-03, release date: 2017-12-06, Last modification date: 2019-11-20)

• Primary citation: Ring, N.G.,Herndler-Brandstetter, D.,Weiskopf, K.,Shan, L.,Volkmer, J.P.,George, B.M.,Lietzenmayer, M.,McKenna, K.M.,Naik, T.J.,McCarty, A.,Zheng, Y.,Ring, A.M.,Flavell, R.A.,Weissman, I.L.; Anti-SIRP alpha antibody immunotherapy enhances neutrophil and macrophage antitumor activity.; Proc. Natl. Acad. Sci. U.S.A., 114:E10578-E10585, 2017; PubMed: 29158380; DOI: 10.1073/pnas.1710877114

Experimental method

X-RAY DIFFRACTION (2.191 Å)