6BG5
Structure of 1-(benzo[d][1,3]dioxol-5-ylmethyl)-1-(1-propylpiperidin-4-yl)-3-(3-(trifluoromethyl)phenyl)urea bound to DCN1
Summary for 6BG5
Entry DOI | 10.2210/pdb6bg5/pdb |
Descriptor | Endolysin, DCN1-like protein 1 chimera, N-[(2H-1,3-benzodioxol-5-yl)methyl]-N-(1-propylpiperidin-4-yl)-N'-[3-(trifluoromethyl)phenyl]urea (3 entities in total) |
Functional Keywords | e3 ligase, hydrolase, ligase-inhibitor complex, ligase/inhibitor |
Biological source | Enterobacteria phage T4 More |
Total number of polymer chains | 1 |
Total formula weight | 44770.85 |
Authors | Guy, R.K.,Schulman, B.A.,Scott, D.C.,Hammill, J.T. (deposition date: 2017-10-27, release date: 2018-09-26, Last modification date: 2023-10-04) |
Primary citation | Hammill, J.T.,Scott, D.C.,Min, J.,Connelly, M.C.,Holbrook, G.,Zhu, F.,Matheny, A.,Yang, L.,Singh, B.,Schulman, B.A.,Guy, R.K. Piperidinyl Ureas Chemically Control Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation. J. Med. Chem., 61:2680-2693, 2018 Cited by PubMed: 29547696DOI: 10.1021/acs.jmedchem.7b01277 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.1 Å) |
Structure validation
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