6BBX

Crystal structure of TnmS3 in complex with TNM C

6BBX の概要

• エントリーDOI: 10.2210/pdb6bbx/pdb
• 分子名称: Glyoxalase/bleomycin resisance protein/dioxygenase, methyl (2R,3R)-2,3-dihydroxy-3-[(1aS,11S,11aR,14Z,18R)-3,7,8,18-tetrahydroxy-4,9-dioxo-4,9,10,11-tetrahydro-11aH-11,1a-hept[3]ene[1,5]diynonaphtho[2,3-h]oxireno[c]quinolin-11a-yl]butanoate (3 entities in total)
• 機能のキーワード: glyoxalase/bleomycin resistance protein/dioxygenase superfamily, structural genomics, midwest center for structural genomics, mcsg, lyase, tiancimycin-binding protein
• 由来する生物種: Streptomyces sp. CB03234
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 32149.61

構造登録者

Chang, C.Y.,Chang, C.,Nocek, B.,Rudolf, J.D.,Joachimiak, A.,Phillips Jr., G.N.,Shen, B.,Enzyme Discovery for Natural Product Biosynthesis (NatPro),Midwest Center for Structural Genomics (MCSG) (登録日: 2017-10-19, 公開日: 2018-07-04, 最終更新日: 2023-10-04)

• 主引用文献: Chang, C.Y.,Yan, X.,Crnovcic, I.,Annaval, T.,Chang, C.,Nocek, B.,Rudolf, J.D.,Yang, D.,Babnigg, G.,Joachimiak, A.,Phillips Jr., G.N.,Shen, B.; Resistance to Enediyne Antitumor Antibiotics by Sequestration.; Cell Chem Biol, 25:1075-1085.e4, 2018; PubMed: 29937405; DOI: 10.1016/j.chembiol.2018.05.012

実験手法

X-RAY DIFFRACTION (2.2 Å)