6BAZ
Lactate Dehydrogenase in complex with inhibitor (S)-5-((2-chlorophenyl)thio)-6'-((4-fluorophenyl)amino)-4-hydroxy-2-(thiophen-3-yl)-2,3-dihydro-[2,2'-bipyridin]-6(1H)-one
Summary for 6BAZ
Entry DOI | 10.2210/pdb6baz/pdb |
Related | 6BAD 6BAG 6BAX |
Descriptor | L-lactate dehydrogenase A chain, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... (7 entities in total) |
Functional Keywords | inhibitor, oxidoreductase, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 151112.77 |
Authors | Ultsch, M.,Eigenbrot, C. (deposition date: 2017-10-16, release date: 2018-10-24, Last modification date: 2023-11-15) |
Primary citation | Wei, B.,Labadie, S.S.,Robarge, K.,Chen, J.,Chen, Z.,Corson, L.B.,Ding, C.Z.,DiPasquale, A.G.,Dragovich, P.S.,Eigenbrot, C.,Evangelista, M.,Fauber, B.P.,Goa, Z.,Ge, H.,Hitz, A.,Ho, Q.,Lai, K.W.,Liu, W.,Liu, Y.,Li, C.,Ma, S.,Malek, S.,O'Brien, T.,Pang, J.,Peterson, D.,Salphati, L.,Sideris, S.,Ultsch, M.,Yen, I.,Yue, Q.,Zhang, H.,Zhou, A.,Purkey, H.E. Structure-guided optimization and in vivo activities of hydroxylactone and hydroxylactam Inhibitors of Human Lactate Dehydrogenase To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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