6B8E

Multiconformer model of apo WT PTP1B with glycerol at 180 K

6B8E の概要

• エントリーDOI: 10.2210/pdb6b8e/pdb
• 分子名称: Tyrosine-protein phosphatase non-receptor type 1, GLYCEROL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (4 entities in total)
• 機能のキーワード: protein tyrosine phosphatase, ptp, protein tyrosine phosphatase 1b, ptp1b, enzyme, allostery, multitemperature, multiconformer, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37836.08

構造登録者

Keedy, D.A.,Hill, Z.B.,Biel, J.T.,Kang, E.,Rettenmaier, T.J.,Brandao-Neto, J.,von Delft, F.,Wells, J.A.,Fraser, J.S. (登録日: 2017-10-06, 公開日: 2018-06-20, 最終更新日: 2024-05-22)

• 主引用文献: Keedy, D.A.,Hill, Z.B.,Biel, J.T.,Kang, E.,Rettenmaier, T.J.,Brandao-Neto, J.,Pearce, N.M.,von Delft, F.,Wells, J.A.,Fraser, J.S.; An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering.; Elife, 7:-, 2018; PubMed: 29877794; DOI: 10.7554/eLife.36307

実験手法

X-RAY DIFFRACTION (1.82 Å)