6B6D

Beta-Lactamase, mixed with Ceftriaxone, needles crystal form, 100ms

6B6D の概要

• エントリーDOI: 10.2210/pdb6b6d/pdb
• 関連するPDBエントリー: 6b6b 6b6c
• 分子名称: Beta-lactamase, (2R)-2-[(1S)-1-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-2-hydroxyethyl]-5-methylidene-5,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, Ceftriaxone, ... (4 entities in total)
• 機能のキーワード: beta-lactamase, antibiotic, hydrolase-antibiotic complex, hydrolase/antibiotic
• 由来する生物種: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29354.88

構造登録者

Pandey, S.,Schmidt, M. (登録日: 2017-10-01, 公開日: 2018-06-27, 最終更新日: 2024-03-13)

主引用文献

Olmos, J.L.,Pandey, S.,Martin-Garcia, J.M.,Calvey, G.,Katz, A.,Knoska, J.,Kupitz, C.,Hunter, M.S.,Liang, M.,Oberthuer, D.,Yefanov, O.,Wiedorn, M.,Heyman, M.,Holl, M.,Pande, K.,Barty, A.,Miller, M.D.,Stern, S.,Roy-Chowdhury, S.,Coe, J.,Nagaratnam, N.,Zook, J.,Verburgt, J.,Norwood, T.,Poudyal, I.,Xu, D.,Koglin, J.,Seaberg, M.H.,Zhao, Y.,Bajt, S.,Grant, T.,Mariani, V.,Nelson, G.,Subramanian, G.,Bae, E.,Fromme, R.,Fung, R.,Schwander, P.,Frank, M.,White, T.A.,Weierstall, U.,Zatsepin, N.,Spence, J.,Fromme, P.,Chapman, H.N.,Pollack, L.,Tremblay, L.,Ourmazd, A.,Phillips, G.N.,Schmidt, M.
Enzyme intermediates captured "on the fly" by mix-and-inject serial crystallography.
BMC Biol., 16:59-59, 2018

PubMed Abstract: Ever since the first atomic structure of an enzyme was solved, the discovery of the mechanism and dynamics of reactions catalyzed by biomolecules has been the key goal for the understanding of the molecular processes that drive life on earth. Despite a large number of successful methods for trapping reaction intermediates, the direct observation of an ongoing reaction has been possible only in rare and exceptional cases.

PubMed: 29848358
DOI: 10.1186/s12915-018-0524-5

実験手法

X-RAY DIFFRACTION (1.8 Å)