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6B5X

Beta-Lactamase, unmixed shards crystal form

Summary for 6B5X
Entry DOI10.2210/pdb6b5x/pdb
DescriptorBeta-lactamase, PHOSPHATE ION (3 entities in total)
Functional Keywordsbeta-lactamase, antibiotic, hydrolase
Biological sourceMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Total number of polymer chains4
Total formula weight113983.29
Authors
Pandey, S. (deposition date: 2017-09-29, release date: 2018-06-27, Last modification date: 2024-03-13)
Primary citationOlmos, J.L.,Pandey, S.,Martin-Garcia, J.M.,Calvey, G.,Katz, A.,Knoska, J.,Kupitz, C.,Hunter, M.S.,Liang, M.,Oberthuer, D.,Yefanov, O.,Wiedorn, M.,Heyman, M.,Holl, M.,Pande, K.,Barty, A.,Miller, M.D.,Stern, S.,Roy-Chowdhury, S.,Coe, J.,Nagaratnam, N.,Zook, J.,Verburgt, J.,Norwood, T.,Poudyal, I.,Xu, D.,Koglin, J.,Seaberg, M.H.,Zhao, Y.,Bajt, S.,Grant, T.,Mariani, V.,Nelson, G.,Subramanian, G.,Bae, E.,Fromme, R.,Fung, R.,Schwander, P.,Frank, M.,White, T.A.,Weierstall, U.,Zatsepin, N.,Spence, J.,Fromme, P.,Chapman, H.N.,Pollack, L.,Tremblay, L.,Ourmazd, A.,Phillips, G.N.,Schmidt, M.
Enzyme intermediates captured "on the fly" by mix-and-inject serial crystallography.
BMC Biol., 16:59-59, 2018
Cited by
PubMed Abstract: Ever since the first atomic structure of an enzyme was solved, the discovery of the mechanism and dynamics of reactions catalyzed by biomolecules has been the key goal for the understanding of the molecular processes that drive life on earth. Despite a large number of successful methods for trapping reaction intermediates, the direct observation of an ongoing reaction has been possible only in rare and exceptional cases.
PubMed: 29848358
DOI: 10.1186/s12915-018-0524-5
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.45 Å)
Structure validation

237992

数据于2025-06-25公开中

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