6B5J
TNNI3K complexed with a 4,6-diaminopyrimidine
Summary for 6B5J
Entry DOI | 10.2210/pdb6b5j/pdb |
Descriptor | Serine/threonine-protein kinase TNNI3K, N-methyl-3-[(6-{[4-(trifluoromethyl)phenyl]amino}pyrimidin-4-yl)amino]benzene-1-sulfonamide (3 entities in total) |
Functional Keywords | kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : Q59H18 |
Total number of polymer chains | 4 |
Total formula weight | 141247.10 |
Authors | Shewchuk, L.M.,Philp, J. (deposition date: 2017-09-29, release date: 2018-04-04, Last modification date: 2024-03-13) |
Primary citation | Philp, J.,Lawhorn, B.G.,Graves, A.P.,Shewchuk, L.,Rivera, K.L.,Jolivette, L.J.,Holt, D.A.,Gatto, G.J.,Kallander, L.S. 4,6-Diaminopyrimidines as Highly Preferred Troponin I-Interacting Kinase (TNNI3K) Inhibitors. J. Med. Chem., 61:3076-3088, 2018 Cited by PubMed: 29561151DOI: 10.1021/acs.jmedchem.8b00125 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.97 Å) |
Structure validation
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