6B5J

TNNI3K complexed with a 4,6-diaminopyrimidine

6B5J の概要

• エントリーDOI: 10.2210/pdb6b5j/pdb
• 分子名称: Serine/threonine-protein kinase TNNI3K, N-methyl-3-[(6-{[4-(trifluoromethyl)phenyl]amino}pyrimidin-4-yl)amino]benzene-1-sulfonamide (3 entities in total)
• 機能のキーワード: kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus : Q59H18
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 141247.10

構造登録者

Shewchuk, L.M.,Philp, J. (登録日: 2017-09-29, 公開日: 2018-04-04, 最終更新日: 2024-03-13)

• 主引用文献: Philp, J.,Lawhorn, B.G.,Graves, A.P.,Shewchuk, L.,Rivera, K.L.,Jolivette, L.J.,Holt, D.A.,Gatto, G.J.,Kallander, L.S.; 4,6-Diaminopyrimidines as Highly Preferred Troponin I-Interacting Kinase (TNNI3K) Inhibitors.; J. Med. Chem., 61:3076-3088, 2018; PubMed: 29561151; DOI: 10.1021/acs.jmedchem.8b00125

実験手法

X-RAY DIFFRACTION (2.97 Å)