6B5F

Crystal structure of nicotinate mononucleotide-5,6-dimethylbenzimidazole phosphoribosyltransferase CobT from Yersinia enterocolitica

6B5F の概要

• エントリーDOI: 10.2210/pdb6b5f/pdb
• 分子名称: Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase, SULFATE ION, CHLORIDE ION, ... (5 entities in total)
• 機能のキーワード: phosphoribosyltransferase, 5, 6-dimethylbenzimidazole, nicotinate mononucleotide, transferase, structural genomics, csgid, center for structural genomics of infectious diseases, niaid, national institute of allergy and infectious diseases
• 由来する生物種: Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 73572.22

構造登録者

Stogios, P.J.,Skarina, T.,McChesney, C.,Grimshaw, T.,Savchenko, A.,Anderson, W.F.,Center for Structural Genomics of Infectious Diseases (CSGID) (登録日: 2017-09-29, 公開日: 2017-10-18, 最終更新日: 2025-06-18)

主引用文献

Inniss, N.L.,Minasov, G.,Chang, C.,Tan, K.,Kim, Y.,Maltseva, N.,Stogios, P.,Filippova, E.,Michalska, K.,Osipiuk, J.,Jaroszewki, L.,Godzik, A.,Savchenko, A.,Joachimiak, A.,Anderson, W.F.,Satchell, K.J.F.
Structural genomics of bacterial drug targets: Application of a high-throughput pipeline to solve 58 protein structures from pathogenic and related bacteria.
Microbiol Resour Announc, :e0020025-e0020025, 2025

PubMed Abstract: Antibiotic resistance remains a leading cause of severe infections worldwide. Small changes in protein sequence can impact antibiotic efficacy. Here, we report deposition of 58 X-ray crystal structures of bacterial proteins that are known targets for antibiotics, which expands knowledge of structural variation to support future antibiotic discovery or modifications.

PubMed: 40391899
DOI: 10.1128/mra.00200-25

実験手法

X-RAY DIFFRACTION (1.95 Å)