6B4D

Crystal structure of human carbonic anhydrase II in complex with a heteroaryl-pyrazole carboxylic acid derivative.

Replaces:  5CJL

Summary for 6B4D

• Entry DOI: 10.2210/pdb6b4d/pdb
• Descriptor: Carbonic anhydrase 2, ZINC ION, DIMETHYL SULFOXIDE, ... (6 entities in total)
• Functional Keywords: carbonic anhydrase, inhibitor, carboxylic acid, lyase
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm : P00918
• Total number of polymer chains: 1
• Total formula weight: 29515.71

Authors

Lomelino, C.L.,Mahon, B.P.,McKenna, R. (deposition date: 2017-09-26, release date: 2018-02-07, Last modification date: 2023-10-04)

• Primary citation: Cadoni, R.,Pala, N.,Lomelino, C.,Mahon, B.P.,McKenna, R.,Dallocchio, R.,Dessi, A.,Carcelli, M.,Rogolino, D.,Sanna, V.,Rassu, M.,Iaccarino, C.,Vullo, D.,Supuran, C.T.,Sechi, M.; Exploring Heteroaryl-pyrazole Carboxylic Acids as Human Carbonic Anhydrase XII Inhibitors.; ACS Med Chem Lett, 8:941-946, 2017; PubMed: 28947941; DOI: 10.1021/acsmedchemlett.7b00229

Experimental method

X-RAY DIFFRACTION (1.196 Å)