6B4D
Crystal structure of human carbonic anhydrase II in complex with a heteroaryl-pyrazole carboxylic acid derivative.
Replaces: 5CJLSummary for 6B4D
Entry DOI | 10.2210/pdb6b4d/pdb |
Descriptor | Carbonic anhydrase 2, ZINC ION, DIMETHYL SULFOXIDE, ... (6 entities in total) |
Functional Keywords | carbonic anhydrase, inhibitor, carboxylic acid, lyase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : P00918 |
Total number of polymer chains | 1 |
Total formula weight | 29515.71 |
Authors | Lomelino, C.L.,Mahon, B.P.,McKenna, R. (deposition date: 2017-09-26, release date: 2018-02-07, Last modification date: 2023-10-04) |
Primary citation | Cadoni, R.,Pala, N.,Lomelino, C.,Mahon, B.P.,McKenna, R.,Dallocchio, R.,Dessi, A.,Carcelli, M.,Rogolino, D.,Sanna, V.,Rassu, M.,Iaccarino, C.,Vullo, D.,Supuran, C.T.,Sechi, M. Exploring Heteroaryl-pyrazole Carboxylic Acids as Human Carbonic Anhydrase XII Inhibitors. ACS Med Chem Lett, 8:941-946, 2017 Cited by PubMed: 28947941DOI: 10.1021/acsmedchemlett.7b00229 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.196 Å) |
Structure validation
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