6B4A

Crystal structure of the C-Terminal Domain of Doublecortin (TgDCX) from Toxoplasma gondii ME49

Summary for 6B4A

• Entry DOI: 10.2210/pdb6b4a/pdb
• Descriptor: Doublecortin, FORMIC ACID (3 entities in total)
• Functional Keywords: structural genomics, ssgcid, toxoplasma gondii, doublecortin, tgdcx, seattle structural genomics center for infectious disease, structural protein
• Biological source: Toxoplasma gondii
• Total number of polymer chains: 2
• Total formula weight: 24537.88

Authors

Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2017-09-26, release date: 2017-10-18, Last modification date: 2024-03-13)

Primary citation

Leung, J.M.,Nagayasu, E.,Hwang, Y.C.,Liu, J.,Pierce, P.G.,Phan, I.Q.,Prentice, R.A.,Murray, J.M.,Hu, K.
A doublecortin-domain protein of Toxoplasma and its orthologues bind to and modify the structure and organization of tubulin polymers.
Bmc Mol Cell Biol, 21:8-8, 2020

PubMed Abstract: TgDCX is a doublecortin-domain protein associated with the conoid fibers, a set of strongly curved non-tubular tubulin-polymers in Toxoplasma. TgDCX deletion impairs conoid structure and parasite invasion. TgDCX contains two tubulin-binding domains: a partial P25α and the DCX/doublecortin domain. Orthologues are found in apicomplexans and their free-living relatives Chromera and Vitrella.

PubMed: 32111164
DOI: 10.1186/s12860-020-0249-5

Experimental method

X-RAY DIFFRACTION (2 Å)