6B22

Crystal structure OXA-24 beta-lactamase complexed with WCK 4234 by co-crystallization

Summary for 6B22

• Entry DOI: 10.2210/pdb6b22/pdb
• Descriptor: Beta-lactamase, (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carbonitrile, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: inhibitor, complex, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Acinetobacter baumannii
• Total number of polymer chains: 1
• Total formula weight: 27863.81

Authors

van den Akker, F.,Nguyen, N.Q. (deposition date: 2017-09-19, release date: 2018-08-01, Last modification date: 2024-03-13)

• Primary citation: Papp-Wallace, K.M.,Nguyen, N.Q.,Jacobs, M.R.,Bethel, C.R.,Barnes, M.D.,Kumar, V.,Bajaksouzian, S.,Rudin, S.D.,Rather, P.N.,Bhavsar, S.,Ravikumar, T.,Deshpande, P.K.,Patil, V.,Yeole, R.,Bhagwat, S.S.,Patel, M.V.,van den Akker, F.,Bonomo, R.A.; Strategic Approaches to Overcome Resistance against Gram-Negative Pathogens Using beta-Lactamase Inhibitors and beta-Lactam Enhancers: Activity of Three Novel Diazabicyclooctanes WCK 5153, Zidebactam (WCK 5107), and WCK 4234.; J. Med. Chem., 61:4067-4086, 2018; PubMed: 29627985; DOI: 10.1021/acs.jmedchem.8b00091

Experimental method

X-RAY DIFFRACTION (1.93 Å)