6B1Y

Crystal structure KPC-2 beta-lactamase complexed with WCK 5153 by co-crystallization

6B1Y の概要

• エントリーDOI: 10.2210/pdb6b1y/pdb
• 関連するPDBエントリー: 6B1X
• 分子名称: Carbapenem-hydrolyzing beta-lactamase KPC, (2S,5Z)-1-formyl-5-imino-N'-[(3R)-1-(sulfooxy)pyrrolidine-3-carbonyl]piperidine-2-carbohydrazide, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: inhibitor, complex, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Klebsiella pneumoniae
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 58195.94

構造登録者

van den Akker, F.,Nguyen, N.Q. (登録日: 2017-09-19, 公開日: 2018-08-01)

• 主引用文献: Papp-Wallace, K.M.,Nguyen, N.Q.,Jacobs, M.R.,Bethel, C.R.,Barnes, M.D.,Kumar, V.,Bajaksouzian, S.,Rudin, S.D.,Rather, P.N.,Bhavsar, S.,Ravikumar, T.,Deshpande, P.K.,Patil, V.,Yeole, R.,Bhagwat, S.S.,Patel, M.V.,van den Akker, F.,Bonomo, R.A.; Strategic Approaches to Overcome Resistance against Gram-Negative Pathogens Using beta-Lactamase Inhibitors and beta-Lactam Enhancers: Activity of Three Novel Diazabicyclooctanes WCK 5153, Zidebactam (WCK 5107), and WCK 4234.; J. Med. Chem., 61:4067-4086, 2018; PubMed: 29627985; DOI: 10.1021/acs.jmedchem.8b00091

実験手法

X-RAY DIFFRACTION (1.8 Å)