6B1H
Crystal structure KPC-2 beta-lactamase complexed with WCK 4234 by co-crystallization
Summary for 6B1H
Entry DOI | 10.2210/pdb6b1h/pdb |
Related | 6B1F |
Descriptor | Carbapenem-hydrolyzing beta-lactamase KPC, (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carbonitrile, SULFATE ION, ... (6 entities in total) |
Functional Keywords | inhibitor, complex, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Klebsiella pneumoniae |
Total number of polymer chains | 2 |
Total formula weight | 57769.58 |
Authors | |
Primary citation | Papp-Wallace, K.M.,Nguyen, N.Q.,Jacobs, M.R.,Bethel, C.R.,Barnes, M.D.,Kumar, V.,Bajaksouzian, S.,Rudin, S.D.,Rather, P.N.,Bhavsar, S.,Ravikumar, T.,Deshpande, P.K.,Patil, V.,Yeole, R.,Bhagwat, S.S.,Patel, M.V.,van den Akker, F.,Bonomo, R.A. Strategic Approaches to Overcome Resistance against Gram-Negative Pathogens Using beta-Lactamase Inhibitors and beta-Lactam Enhancers: Activity of Three Novel Diazabicyclooctanes WCK 5153, Zidebactam (WCK 5107), and WCK 4234. J. Med. Chem., 61:4067-4086, 2018 Cited by PubMed: 29627985DOI: 10.1021/acs.jmedchem.8b00091 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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