6AX8

Mycobacterium tuberculosis methionyl-tRNA synthetase in complex with methionyl-adenylate

Summary for 6AX8

Entry DOI	10.2210/pdb6ax8/pdb
Descriptor	Methionine-tRNA ligase, [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl] (2S)-2-azanyl-4-methylsulfanyl-butanoate (3 entities in total)
Functional Keywords	synthetase, ligase, ligase-aminoacyl adenylate complex
Biological source	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Total number of polymer chains	1
Total formula weight	58636.82
Authors	Barros-Alvarez, X.,Hol, W.G.J. (deposition date: 2017-09-06, release date: 2018-04-11, Last modification date: 2024-03-13)
Primary citation	Barros-Alvarez, X.,Turley, S.,Ranade, R.M.,Gillespie, J.R.,Duster, N.A.,Verlinde, C.L.M.J.,Fan, E.,Buckner, F.S.,Hol, W.G.J. The crystal structure of the drug target Mycobacterium tuberculosis methionyl-tRNA synthetase in complex with a catalytic intermediate. Acta Crystallogr F Struct Biol Commun, 74:245-254, 2018 Cited by PubMed: 29633973 DOI: 10.1107/S2053230X18003151 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation