6AVM

STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING D4TTP AT PH 9.5 WITH CROSS-LINKING TO SECOND BASE TEMPLATE OVERHANG

6AVM の概要

• エントリーDOI: 10.2210/pdb6avm/pdb
• 分子名称: HIV-1 REVERSE TRANSCRIPTASE P66 SUBUNIT, HIV-1 REVERSE TRANSCRIPTASE P51 SUBUNIT, DNA (27-MER), ... (8 entities in total)
• 機能のキーワード: rt, dna, crosslink, n site complex, d4t (stavudine), pyrophosphorolysis, p51, p66, transferase-dna complex, viral protein, transcription-dna complex, transferase/dna
• 由来する生物種: Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1); 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 263617.69

構造登録者

Martinez, S.E.,Das, K.,Arnold, E. (登録日: 2017-09-03, 公開日: 2018-08-15, 最終更新日: 2023-10-04)

• 主引用文献: Martinez, S.E.,Bauman, J.D.,Das, K.,Arnold, E.; Structure of HIV-1 reverse transcriptase/d4TTP complex: Novel DNA cross-linking site and pH-dependent conformational changes.; Protein Sci., 28:587-597, 2019; PubMed: 30499174; DOI: 10.1002/pro.3559

実験手法

X-RAY DIFFRACTION (2.502 Å)