6AUV

Structure of rat neuronal nitric oxide synthase heme domain in complex with 4-Methyl-6-(2-(5-(3-((methylamino)methyl)phenyl)pyridin-3-yl)ethyl)pyridin-2-amine

6AUV の概要

• エントリーDOI: 10.2210/pdb6auv/pdb
• 分子名称: Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total)
• 機能のキーワード: nitric oxide synthase inhibitor heme enzyme, oxidoreductase, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
• 由来する生物種: Rattus norvegicus (Rat)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 100188.90

構造登録者

Li, H.,Poulos, T.L. (登録日: 2017-09-01, 公開日: 2018-07-11, 最終更新日: 2023-10-04)

• 主引用文献: Do, H.T.,Wang, H.Y.,Li, H.,Chreifi, G.,Poulos, T.L.,Silverman, R.B.; Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with a Fluorobenzene Linker.; J. Med. Chem., 60:9360-9375, 2017; PubMed: 29091437; DOI: 10.1021/acs.jmedchem.7b01356

実験手法

X-RAY DIFFRACTION (1.76 Å)