6ASQ

Structure of Grp94 bound to methyl 2-[2-(2-benzylpyridin-3-yl)ethyl]-3-chloro-4,6-dihydroxybenzoate, a pan-Hsp90 inhibitor

Summary for 6ASQ

Entry DOI	10.2210/pdb6asq/pdb
Descriptor	Endoplasmin, 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, DI(HYDROXYETHYL)ETHER, ... (6 entities in total)
Functional Keywords	grp94, hsp90, inhibitor, chaperone-inhibitor complex, chaperone/inhibitor
Biological source	Canis lupus familiaris (Dog) More
Total number of polymer chains	2
Total formula weight	58673.34
Authors	Huard, D.J.E.,Lieberman, R.L. (deposition date: 2017-08-25, release date: 2018-04-18, Last modification date: 2023-10-04)
Primary citation	Huard, D.J.E.,Crowley, V.M.,Du, Y.,Cordova, R.A.,Sun, Z.,Tomlin, M.O.,Dickey, C.A.,Koren, J.,Blair, L.,Fu, H.,Blagg, B.S.J.,Lieberman, R.L. Trifunctional High-Throughput Screen Identifies Promising Scaffold To Inhibit Grp94 and Treat Myocilin-Associated Glaucoma. ACS Chem. Biol., 13:933-941, 2018 Cited by PubMed: 29402077 DOI: 10.1021/acschembio.7b01083 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.35 Å)

Structure validation