6ASQ

Structure of Grp94 bound to methyl 2-[2-(2-benzylpyridin-3-yl)ethyl]-3-chloro-4,6-dihydroxybenzoate, a pan-Hsp90 inhibitor

6ASQ の概要

• エントリーDOI: 10.2210/pdb6asq/pdb
• 分子名称: Endoplasmin, 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, DI(HYDROXYETHYL)ETHER, ... (6 entities in total)
• 機能のキーワード: grp94, hsp90, inhibitor, chaperone-inhibitor complex, chaperone/inhibitor
• 由来する生物種: Canis lupus familiaris (Dog); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 58673.34

構造登録者

Huard, D.J.E.,Lieberman, R.L. (登録日: 2017-08-25, 公開日: 2018-04-18, 最終更新日: 2023-10-04)

• 主引用文献: Huard, D.J.E.,Crowley, V.M.,Du, Y.,Cordova, R.A.,Sun, Z.,Tomlin, M.O.,Dickey, C.A.,Koren, J.,Blair, L.,Fu, H.,Blagg, B.S.J.,Lieberman, R.L.; Trifunctional High-Throughput Screen Identifies Promising Scaffold To Inhibit Grp94 and Treat Myocilin-Associated Glaucoma.; ACS Chem. Biol., 13:933-941, 2018; PubMed: 29402077; DOI: 10.1021/acschembio.7b01083

実験手法

X-RAY DIFFRACTION (2.35 Å)