6ARY

Crystal structure of an insecticide-resistant acetylcholinesterase mutant from the malaria vector Anopheles gambiae in complex with a difluoromethyl ketone inhibitor

6ARY の概要

• エントリーDOI: 10.2210/pdb6ary/pdb
• 分子名称: Acetylcholinesterase, (1S)-2,2-difluoro-1-[1-(pentan-3-yl)-1H-pyrazol-4-yl]ethan-1-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: hydrolase, difluoromethyl ketone, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Anopheles gambiae (African malaria mosquito)
• 細胞内の位置: Cell junction, synapse: Q869C3
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 123187.96

構造登録者

Cheung, J.,Mahmood, A.,Kalathur, R.,Lixuan, L.,Carlier, P.R. (登録日: 2017-08-23, 公開日: 2018-01-10, 最終更新日: 2023-10-04)

• 主引用文献: Cheung, J.,Mahmood, A.,Kalathur, R.,Liu, L.,Carlier, P.R.; Structure of the G119S Mutant Acetylcholinesterase of the Malaria Vector Anopheles gambiae Reveals Basis of Insecticide Resistance.; Structure, 26:130-136.e2, 2018; PubMed: 29276037; DOI: 10.1016/j.str.2017.11.021

実験手法

X-RAY DIFFRACTION (2.257 Å)