6ARX

Crystal structure of an insecticide-resistant acetylcholinesterase mutant from the malaria vector Anopheles gambiae in the ligand-free state

Summary for 6ARX

Entry DOI	10.2210/pdb6arx/pdb
Descriptor	Acetylcholinesterase, 2-acetamido-2-deoxy-beta-D-glucopyranose, CITRATE ANION, ... (5 entities in total)
Functional Keywords	hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Anopheles gambiae (African malaria mosquito)
Cellular location	Cell junction, synapse: Q869C3
Total number of polymer chains	2
Total formula weight	122691.41
Authors	Cheung, J.,Mahmood, A.,Kalathur, R.,Lixuan, L.,Carlier, P.R. (deposition date: 2017-08-23, release date: 2018-01-10, Last modification date: 2023-10-04)
Primary citation	Cheung, J.,Mahmood, A.,Kalathur, R.,Liu, L.,Carlier, P.R. Structure of the G119S Mutant Acetylcholinesterase of the Malaria Vector Anopheles gambiae Reveals Basis of Insecticide Resistance. Structure, 26:130-136.e2, 2018 Cited by PubMed: 29276037 DOI: 10.1016/j.str.2017.11.021 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.302 Å)

Structure validation