6AR9
Crystal structure of hypoxanthine-guanine-xanthine phosphorybosyltranferase in complex with [(2-{[2-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)ethyl][(E)-2-phosphonoethenyl]amino}ethoxy)methyl]phosphonic acid
Summary for 6AR9
Entry DOI | 10.2210/pdb6ar9/pdb |
Descriptor | Hypoxanthine-guanine phosphoribosyltransferase, putative, [(2-{[2-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)ethyl][(E)-2-phosphonoethenyl]amino}ethoxy)methyl]phosphonic acid, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | purine salvage, acyclic nucleoside phosphonates, transferase |
Biological source | Trypanosoma brucei brucei (strain 927/4 GUTat10.1) More |
Total number of polymer chains | 6 |
Total formula weight | 186713.74 |
Authors | Teran, D.,Gudday, L.W. (deposition date: 2017-08-21, release date: 2018-03-14, Last modification date: 2023-11-15) |
Primary citation | Dolezelova, E.,Teran, D.,Gahura, O.,Kotrbova, Z.,Prochazkova, M.,Keough, D.,Spacek, P.,Hockova, D.,Guddat, L.,Zikova, A. Evaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery. PLoS Negl Trop Dis, 12:e0006301-e0006301, 2018 Cited by PubMed: 29481567DOI: 10.1371/journal.pntd.0006301 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.28 Å) |
Structure validation
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