6AQV

Crystal Structure of Z-DNA with 6-fold Twinning_Z3B

6AQV の概要

• エントリーDOI: 10.2210/pdb6aqv/pdb
• 分子名称: DNA (5'-D(*CP*GP*CP*GP*CP*G)-3') (2 entities in total)
• 機能のキーワード: z-dna, twinning, dna
• 由来する生物種: synthetic construct
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 10861.23

構造登録者

Luo, Z.,Dauter, Z.,Gilski, M. (登録日: 2017-08-21, 公開日: 2017-08-30, 最終更新日: 2023-10-04)

主引用文献

Luo, Z.,Dauter, Z.,Gilski, M.
Four highly pseudosymmetric and/or twinned structures of d(CGCGCG)2 extend the repertoire of crystal structures of Z-DNA.
Acta Crystallogr D Struct Biol, 73:940-951, 2017

PubMed Abstract: DNA oligomer duplexes containing alternating cytosines and guanines in their sequences tend to form left-handed helices of the Z-DNA type, with the sugar and phosphate backbone in a zigzag conformation and a helical repeat of two successive nucleotides. Z-DNA duplexes usually crystallize as hexagonally arranged parallel helical tubes, with various relative orientations and translation of neighboring duplexes. Four novel high-resolution crystal structures of d(CGCGCG) duplexes are described here. They are characterized by a high degree of pseudosymmetry and/or twinning, with three or four independent duplexes differently oriented in a monoclinic P2 lattice of hexagonal metric. The various twinning criteria give somewhat conflicting indications in these complicated cases of crystal pathology. The details of molecular packing in these crystal structures are compared with other known crystal forms of Z-DNA.

PubMed: 29095165
DOI: 10.1107/S2059798317014954

実験手法

X-RAY DIFFRACTION (1.3 Å)