6APW

Crystal structure of Staphylococcus aureus biotin protein ligase in complex with inhibitor

6APW の概要

• エントリーDOI: 10.2210/pdb6apw/pdb
• 分子名称: Bifunctional ligase/repressor BirA, 4-[(4-{5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentyl}-1H-1,2,3-triazol-1-yl)methyl]benzoic acid (3 entities in total)
• 機能のキーワード: ligase, inhibitor, antibiotic
• 由来する生物種: Staphylococcus aureus
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38431.29

構造登録者

Cini, D.A.,Wilce, M.C.J. (登録日: 2017-08-18, 公開日: 2018-02-07, 最終更新日: 2024-03-13)

• 主引用文献: Paparella, A.S.,Lee, K.J.,Hayes, A.J.,Feng, J.,Feng, Z.,Cini, D.,Deshmukh, S.,Booker, G.W.,Wilce, M.C.J.,Polyak, S.W.,Abell, A.D.; Halogenation of Biotin Protein Ligase Inhibitors Improves Whole Cell Activity against Staphylococcus aureus.; ACS Infect Dis, 4:175-184, 2018; PubMed: 29131575; DOI: 10.1021/acsinfecdis.7b00134

実験手法

X-RAY DIFFRACTION (2.614 Å)