6AOL
Structure of molecular chaperone Grp94 bound to selective inhibitor methyl 3-chloro-2-(2-{2-[(4-fluorophenyl)methyl]phenyl}ethyl)-4,6-dihydroxybenzoate
Summary for 6AOL
| Entry DOI | 10.2210/pdb6aol/pdb |
| Descriptor | Endoplasmin, methyl 3-chloro-2-(2-{2-[(4-fluorophenyl)methyl]phenyl}ethyl)-4,6-dihydroxybenzoate, 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, ... (4 entities in total) |
| Functional Keywords | grp94, hsp90, chaperone-inhibitor complex, chaperone/inhibitor |
| Biological source | Canis lupus familiaris (Dog) More |
| Cellular location | Endoplasmic reticulum lumen: P41148 |
| Total number of polymer chains | 1 |
| Total formula weight | 27908.00 |
| Authors | Lieberman, R.L.,Huard, D.J.E. (deposition date: 2017-08-16, release date: 2017-10-11, Last modification date: 2023-10-04) |
| Primary citation | Crowley, V.M.,Huard, D.J.E.,Lieberman, R.L.,Blagg, B.S.J. Second Generation Grp94-Selective Inhibitors Provide Opportunities for the Inhibition of Metastatic Cancer. Chemistry, 23:15775-15782, 2017 Cited by PubMed: 28857290DOI: 10.1002/chem.201703398 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.764 Å) |
Structure validation
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