6AM9

Engineered tryptophan synthase b-subunit from Pyrococcus furiosus, PfTrpB2B9, with Ser-bound in a predominantly closed state.

6AM9 の概要

• エントリーDOI: 10.2210/pdb6am9/pdb
• 分子名称: Tryptophan synthase beta chain 1, SODIUM ION, [3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL]-SERINE, ... (5 entities in total)
• 機能のキーワード: plp type ii, tryptophan synthase, engineered, allostery, biosynthetic protein, lyase
• 由来する生物種: Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 174985.19

構造登録者

Buller, A.R.,van Roye, P. (登録日: 2017-08-09, 公開日: 2018-05-16, 最終更新日: 2023-10-04)

• 主引用文献: Buller, A.R.,van Roye, P.,Cahn, J.K.B.,Scheele, R.A.,Herger, M.,Arnold, F.H.; Directed Evolution Mimics Allosteric Activation by Stepwise Tuning of the Conformational Ensemble.; J. Am. Chem. Soc., 140:7256-7266, 2018; PubMed: 29712420; DOI: 10.1021/jacs.8b03490

実験手法

X-RAY DIFFRACTION (2.09 Å)