6AKX

The Crystal structure of Human Chemokine Receptor CCR5 in complex with compound 21

Summary for 6AKX

• Entry DOI: 10.2210/pdb6akx/pdb
• Descriptor: C-C chemokine receptor type 5,Rubredoxin,C-C chemokine receptor type 5, ZINC ION, NITRATE ION, ... (5 entities in total)
• Functional Keywords: g protein-coupled receptor chemokine receptor ccr5 antagonist complex structure, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 88946.65

Authors

Zhu, Y.,Zhao, Q.,Wu, B. (deposition date: 2018-09-04, release date: 2018-10-24, Last modification date: 2023-11-22)

• Primary citation: Peng, P.,Chen, H.,Zhu, Y.,Wang, Z.,Li, J.,Luo, R.H.,Wang, J.,Chen, L.,Yang, L.M.,Jiang, H.,Xie, X.,Wu, B.,Zheng, Y.T.,Liu, H.; Structure-Based Design of 1-Heteroaryl-1,3-propanediamine Derivatives as a Novel Series of CC-Chemokine Receptor 5 Antagonists.; J. Med. Chem., 61:9621-9636, 2018; PubMed: 30234300; DOI: 10.1021/acs.jmedchem.8b01077

Experimental method

X-RAY DIFFRACTION (2.8 Å)