6AKX

The Crystal structure of Human Chemokine Receptor CCR5 in complex with compound 21

6AKX の概要

• エントリーDOI: 10.2210/pdb6akx/pdb
• 分子名称: C-C chemokine receptor type 5,Rubredoxin,C-C chemokine receptor type 5, ZINC ION, NITRATE ION, ... (5 entities in total)
• 機能のキーワード: g protein-coupled receptor chemokine receptor ccr5 antagonist complex structure, signaling protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 88946.65

構造登録者

Zhu, Y.,Zhao, Q.,Wu, B. (登録日: 2018-09-04, 公開日: 2018-10-24, 最終更新日: 2023-11-22)

• 主引用文献: Peng, P.,Chen, H.,Zhu, Y.,Wang, Z.,Li, J.,Luo, R.H.,Wang, J.,Chen, L.,Yang, L.M.,Jiang, H.,Xie, X.,Wu, B.,Zheng, Y.T.,Liu, H.; Structure-Based Design of 1-Heteroaryl-1,3-propanediamine Derivatives as a Novel Series of CC-Chemokine Receptor 5 Antagonists.; J. Med. Chem., 61:9621-9636, 2018; PubMed: 30234300; DOI: 10.1021/acs.jmedchem.8b01077

実験手法

X-RAY DIFFRACTION (2.8 Å)