6AJZ

Joint nentron and X-ray structure of BRD4 in complex with colchicin

6AJZ の概要

• エントリーDOI: 10.2210/pdb6ajz/pdb
• 分子名称: Bromodomain-containing protein 4, N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl]ethanamide, SODIUM ION, ... (4 entities in total)
• 機能のキーワード: bromodomain, brd4, inhibitor, isoliquiritigenin, transcription
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 16582.99

構造登録者

Yokoyama, T.,Ostermann, A.,Schrader, T.E.,Nabeshima, Y.,Mizuguchi, M. (登録日: 2018-08-28, 公開日: 2019-06-12, 最終更新日: 2024-03-27)

• 主引用文献: Yokoyama, T.,Matsumoto, K.,Ostermann, A.,Schrader, T.E.,Nabeshima, Y.,Mizuguchi, M.; Structural and thermodynamic characterization of the binding of isoliquiritigenin to the first bromodomain of BRD4.; Febs J., 286:1656-1667, 2019; PubMed: 30565859; DOI: 10.1111/febs.14736

実験手法

NEUTRON DIFFRACTION (1.847 Å)
X-RAY DIFFRACTION (1.301 Å)