6AFE

DJ-1 with compound 7

6AFE の概要

• エントリーDOI: 10.2210/pdb6afe/pdb
• 分子名称: Protein/nucleic acid deglycase DJ-1, 7-(trifluoromethyl)-1~{H}-indole-2,3-dione, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: dj-1, parkinson's disease, drug discovery, fragment-based drug discovery, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 20382.76

構造登録者

Caaveiro, J.M.M.,Tashiro, S.,Tsumoto, K. (登録日: 2018-08-08, 公開日: 2018-08-29, 最終更新日: 2023-11-22)

• 主引用文献: Tashiro, S.,Caaveiro, J.M.M.,Nakakido, M.,Tanabe, A.,Nagatoishi, S.,Tamura, Y.,Matsuda, N.,Liu, D.,Hoang, Q.Q.,Tsumoto, K.; Discovery and Optimization of Inhibitors of the Parkinson's Disease Associated Protein DJ-1.; ACS Chem. Biol., 13:2783-2793, 2018; PubMed: 30063823; DOI: 10.1021/acschembio.8b00701

実験手法

X-RAY DIFFRACTION (1.5 Å)