6AFB
DJ-1 C106S incubated with isatin
Summary for 6AFB
Entry DOI | 10.2210/pdb6afb/pdb |
Descriptor | Protein/nucleic acid deglycase DJ-1, ISATIN, CHLORIDE ION, ... (5 entities in total) |
Functional Keywords | dj-1, parkinson's disease, drug discovery, fragment-based drug discovery, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 20308.83 |
Authors | Caaveiro, J.M.M.,Tashiro, S.,Tsumoto, K. (deposition date: 2018-08-08, release date: 2018-08-29, Last modification date: 2023-11-22) |
Primary citation | Tashiro, S.,Caaveiro, J.M.M.,Nakakido, M.,Tanabe, A.,Nagatoishi, S.,Tamura, Y.,Matsuda, N.,Liu, D.,Hoang, Q.Q.,Tsumoto, K. Discovery and Optimization of Inhibitors of the Parkinson's Disease Associated Protein DJ-1. ACS Chem. Biol., 13:2783-2793, 2018 Cited by PubMed: 30063823DOI: 10.1021/acschembio.8b00701 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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