6AEJ

Crystal structure of human FTO in complex with small-molecule inhibitors

6AEJ の概要

• エントリーDOI: 10.2210/pdb6aej/pdb
• 分子名称: Alpha-ketoglutarate-dependent dioxygenase FTO,Alpha-ketoglutarate-dependent dioxygenase FTO, (E)-3-[3-nitro-4,5-bis(oxidanyl)phenyl]-2-(1,3-oxazinan-3-ylcarbonyl)prop-2-enenitrile, ZINC ION (3 entities in total)
• 機能のキーワード: oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 54506.65

構造登録者

Wang, Y.,Cao, R.,Peng, S.,Zhang, W.,Huang, N. (登録日: 2018-08-05, 公開日: 2019-06-19, 最終更新日: 2023-11-22)

• 主引用文献: Peng, S.,Xiao, W.,Ju, D.,Sun, B.,Hou, N.,Liu, Q.,Wang, Y.,Zhao, H.,Gao, C.,Zhang, S.,Cao, R.,Li, P.,Huang, H.,Ma, Y.,Wang, Y.,Lai, W.,Ma, Z.,Zhang, W.,Huang, S.,Wang, H.,Zhang, Z.,Zhao, L.,Cai, T.,Zhao, Y.L.,Wang, F.,Nie, Y.,Zhi, G.,Yang, Y.G.,Zhang, E.E.,Huang, N.; Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1.; Sci Transl Med, 11:-, 2019; PubMed: 30996080; DOI: 10.1126/scitranslmed.aau7116

実験手法

X-RAY DIFFRACTION (2.8 Å)