6AD9
Crystal Structure of PPARgamma Ligand Binding Domain in complex with dibenzooxepine derivative compound-9
Summary for 6AD9
Entry DOI | 10.2210/pdb6ad9/pdb |
Descriptor | Peroxisome proliferator-activated receptor gamma, 12-mer peptide from Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, 3-[(1E)-1-{8-[(4-methyl-2-propyl-1H-benzimidazol-1-yl)methyl]dibenzo[b,e]oxepin-11(6H)-ylidene}ethyl]-1,2,4-oxadiazol-5(4H)-one, ... (4 entities in total) |
Functional Keywords | ppargamma ligand binding domain agonist, nuclear protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 34452.02 |
Authors | Takahashi, Y.,Suzuki, M.,Yamamoto, K.,Saito, J. (deposition date: 2018-07-31, release date: 2018-11-14, Last modification date: 2024-03-27) |
Primary citation | Yamamoto, K.,Tamura, T.,Henmi, K.,Kuboyama, T.,Yanagisawa, A.,Matsubara, M.,Takahashi, Y.,Suzuki, M.,Saito, J.I.,Ueno, K.,Shuto, S. Development of Dihydrodibenzooxepine Peroxisome Proliferator-Activated Receptor (PPAR) Gamma Ligands of a Novel Binding Mode as Anticancer Agents: Effective Mimicry of Chiral Structures by Olefinic E/ Z-Isomers. J. Med. Chem., 61:10067-10083, 2018 Cited by PubMed: 30351933DOI: 10.1021/acs.jmedchem.8b01200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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