6A94

Crystal structure of 5-HT2AR in complex with zotepine

Summary for 6A94

Entry DOI	10.2210/pdb6a94/pdb
Descriptor	5-hydroxytryptamine receptor 2A,Soluble cytochrome b562, 2-(3-chloranylbenzo[b][1]benzothiepin-5-yl)oxy-N,N-dimethyl-ethanamine, CHOLESTEROL, ... (7 entities in total)
Functional Keywords	receptor, membrane protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	86215.78
Authors	Kimura, T.K.,Asada, H.,Inoue, A.,Kadji, F.M.N.,Im, D.,Mori, C.,Arakawa, T.,Hirata, K.,Nomura, Y.,Nomura, N.,Aoki, J.,Iwata, S.,Shimamura, T. (deposition date: 2018-07-11, release date: 2019-02-13, Last modification date: 2023-11-22)
Primary citation	Kimura, K.T.,Asada, H.,Inoue, A.,Kadji, F.M.N.,Im, D.,Mori, C.,Arakawa, T.,Hirata, K.,Nomura, Y.,Nomura, N.,Aoki, J.,Iwata, S.,Shimamura, T. Structures of the 5-HT2Areceptor in complex with the antipsychotics risperidone and zotepine. Nat.Struct.Mol.Biol., 26:121-128, 2019 Cited by PubMed: 30723326 DOI: 10.1038/s41594-018-0180-z PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation