6A8N

The crystal structure of muPAin-1-IG-2 in complex with muPA-SPD at pH8.5

Summary for 6A8N

Entry DOI	10.2210/pdb6a8n/pdb
Descriptor	Urokinase-type plasminogen activator B, CYS-PRO-ALA-TYR-SER-ARG-TYR-ILE-GLY-CYS (2 entities in total)
Functional Keywords	peptides inhibitor, mupa, serine protease, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Mus musculus (Mouse) More
Total number of polymer chains	4
Total formula weight	57374.96
Authors	Wang, D.,Yang, Y.S.,Jiang, L.G.,Huang, M.D.,Li, J.Y.,Andreasen, P.A.,Xu, P.,Chen, Z. (deposition date: 2018-07-09, release date: 2019-02-20, Last modification date: 2023-11-22)
Primary citation	Wang, D.,Yang, Y.,Jiang, L.,Wang, Y.,Li, J.,Andreasen, P.A.,Chen, Z.,Huang, M.,Xu, P. Suppression of Tumor Growth and Metastases by Targeted Intervention in Urokinase Activity with Cyclic Peptides. J.Med.Chem., 62:2172-2183, 2019 Cited by PubMed: 30707839 DOI: 10.1021/acs.jmedchem.8b01908 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.489 Å)

Structure validation