6A76
Crystal structure of the Fab fragment of B5209B, a murine monoclonal antibody specific for the fifth immunoglobulin domain (Ig5) of human ROBO1
Summary for 6A76
Entry DOI | 10.2210/pdb6a76/pdb |
Descriptor | Light chain of the anti-human Robo1 antibody B5209B Fab, Heavy chain of the anti-human Robo1 antibody B5209B Fab, GLYCEROL, ... (5 entities in total) |
Functional Keywords | hepatocellular carcinoma antigen, angiogenesis, immune system, antibody drug |
Biological source | Mus musculus More |
Total number of polymer chains | 2 |
Total formula weight | 47246.35 |
Authors | Mizohata, E.,Nakayama, T.,Kado, Y.,Inoue, T. (deposition date: 2018-07-02, release date: 2019-01-30, Last modification date: 2019-03-20) |
Primary citation | Yamashita, T.,Mizohata, E.,Nagatoishi, S.,Watanabe, T.,Nakakido, M.,Iwanari, H.,Mochizuki, Y.,Nakayama, T.,Kado, Y.,Yokota, Y.,Matsumura, H.,Kawamura, T.,Kodama, T.,Hamakubo, T.,Inoue, T.,Fujitani, H.,Tsumoto, K. Affinity Improvement of a Cancer-Targeted Antibody through Alanine-Induced Adjustment of Antigen-Antibody Interface. Structure, 27:519-, 2019 Cited by PubMed: 30595454DOI: 10.1016/j.str.2018.11.002 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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