6A6K

Crystal structure of Estrogen-related Receptor-3 (ERR-gamma) ligand binding domain with DN201000

6A6K の概要

• エントリーDOI: 10.2210/pdb6a6k/pdb
• 分子名称: Estrogen-related receptor gamma, 3-[(~{E})-5-oxidanyl-2-phenyl-1-[4-(4-propan-2-ylpiperazin-1-yl)phenyl]pent-1-enyl]phenol (3 entities in total)
• 機能のキーワード: sodium iodide symporter (nis), anaplastic thyroid cancer, estrogen-related receptor gamma, radioiodine therapy, transcription
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 82395.35

構造登録者

Yoon, H.,Kim, J.,Chin, J.,Cho, S.J.,Song, J. (登録日: 2018-06-28, 公開日: 2019-04-10, 最終更新日: 2023-11-22)

• 主引用文献: Kim, J.,Song, J.,Ji, H.D.,Yoo, E.K.,Lee, J.E.,Lee, S.B.,Oh, J.M.,Lee, S.,Hwang, J.S.,Yoon, H.,Kim, D.S.,Lee, S.J.,Jeong, M.,Lee, S.,Kim, K.H.,Choi, H.S.,Lee, S.W.,Park, K.G.,Lee, I.K.,Kim, S.H.,Hwang, H.,Jeon, Y.H.,Chin, J.,Cho, S.J.; Discovery of Potent, Selective, and Orally Bioavailable Estrogen-Related Receptor-gamma Inverse Agonists To Restore the Sodium Iodide Symporter Function in Anaplastic Thyroid Cancer.; J. Med. Chem., 62:1837-1858, 2019; PubMed: 30657313; DOI: 10.1021/acs.jmedchem.8b01296

実験手法

X-RAY DIFFRACTION (2.9 Å)