6A3N
Crystal structure of the PDE9 catalytic domain in complex with inhibitor 2
Summary for 6A3N
Entry DOI | 10.2210/pdb6a3n/pdb |
Descriptor | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, ZINC ION, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | pde9 inhibitor complex, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 77080.37 |
Authors | Wu, Y.N.,Zhou, Q.,Chen, Y.P.,Luo, H.B. (deposition date: 2018-06-15, release date: 2019-04-10, Last modification date: 2023-11-22) |
Primary citation | Wu, Y.,Zhou, Q.,Zhang, T.,Li, Z.,Chen, Y.P.,Zhang, P.,Yu, Y.F.,Geng, H.,Tian, Y.J.,Zhang, C.,Wang, Y.,Chen, J.W.,Chen, Y.,Luo, H.B. Discovery of Potent, Selective, and Orally Bioavailable Inhibitors against Phosphodiesterase-9, a Novel Target for the Treatment of Vascular Dementia. J. Med. Chem., 62:4218-4224, 2019 Cited by PubMed: 30916555DOI: 10.1021/acs.jmedchem.8b01041 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
Download full validation report