6A36

Mandelate oxidase mutant-Y128F with the 3-fluoropyruvic acid FMN adduct

6A36 の概要

• エントリーDOI: 10.2210/pdb6a36/pdb
• 分子名称: 4-hydroxymandelate oxidase, 1-{5-[(3S)-3-carboxy-4-fluoro-3-hydroxybutanoyl]-7,8-dimethyl-2,4-dioxo-1,3,4,5-tetrahydrobenzo[g]pteridin-10(2H)-yl}-1-deoxy-5-O-phosphono-D-ribitol, 1-deoxy-1-{5-[(1S)-2-fluoro-1-hydroxyethyl]-7,8-dimethyl-2,4-dioxo-1,3,4,5-tetrahydrobenzo[g]pteridin-10(2H)-yl}-5-O-phosphono-D-ribitol, ... (4 entities in total)
• 機能のキーワード: fmn-dependent oxidase, flavoprotein
• 由来する生物種: Amycolatopsis orientalis (Nocardia orientalis)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 41156.41

構造登録者

Li, T.L.,Lin, K.H. (登録日: 2018-06-15, 公開日: 2019-06-19, 最終更新日: 2023-11-22)

• 主引用文献: Lin, K.H.,Lyu, S.Y.,Yeh, H.W.,Li, Y.S.,Hsu, N.S.,Huang, C.M.,Wang, Y.L.,Shih, H.W.,Wang, Z.C.,Wu, C.J.,Li, T.L.; Structural and chemical trapping of flavin-oxide intermediates reveals substrate-directed reaction multiplicity.; Protein Sci., 29:1655-1666, 2020; PubMed: 32362037; DOI: 10.1002/pro.3879

実験手法

X-RAY DIFFRACTION (1.44 Å)