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6A2M

Crystal structure of wild type Plasmodium falciparum DHFR-TS complexed with BT2, NADPH, and dUMP

Summary for 6A2M
Entry DOI10.2210/pdb6a2m/pdb
DescriptorBifunctional dihydrofolate reductase-thymidylate synthase, 5-(4-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)-6-ethylpyrimidine-2,4-diamine, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (6 entities in total)
Functional Keywordsrossmann fold, dual-binding inhibitor, oxidoreductase
Biological sourcePlasmodium falciparum (malaria parasite P. falciparum)
Total number of polymer chains2
Total formula weight146798.11
Authors
Chitnumsub, P.,Jaruwat, A.,Tarnchampoo, B.,Yuthavong, Y. (deposition date: 2018-06-12, release date: 2019-04-24, Last modification date: 2023-11-22)
Primary citationTarnchompoo, B.,Chitnumsub, P.,Jaruwat, A.,Shaw, P.J.,Vanichtanankul, J.,Poen, S.,Rattanajak, R.,Wongsombat, C.,Tonsomboon, A.,Decharuangsilp, S.,Anukunwithaya, T.,Arwon, U.,Kamchonwongpaisan, S.,Yuthavong, Y.
Hybrid Inhibitors of Malarial Dihydrofolate Reductase with Dual Binding Modes That Can Forestall Resistance.
ACS Med Chem Lett, 9:1235-1240, 2018
Cited by
PubMed: 30613332
DOI: 10.1021/acsmedchemlett.8b00389
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.2 Å)
Structure validation

217705

数据于2024-03-27公开中

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