5ZXD

Crystal structure of ATP-bound human ABCF1

5ZXD の概要

• エントリーDOI: 10.2210/pdb5zxd/pdb
• 分子名称: ATP-binding cassette sub-family F member 1, ADENOSINE-5'-TRIPHOSPHATE (3 entities in total)
• 機能のキーワード: regulator, translation
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 127168.45

構造登録者

Qu, L.,Jiang, Y.,Liu, Z.J. (登録日: 2018-05-18, 公開日: 2018-07-25, 最終更新日: 2024-11-13)

主引用文献

Qu, L.,Jiang, Y.,Cheng, C.,Wu, D.,Meng, B.,Chen, Z.,Zhu, Y.,Shaw, N.,Ouyang, S.,Liu, Z.J.
Crystal Structure of ATP-Bound Human ABCF1 Demonstrates a Unique Conformation of ABC Proteins
Structure, 26:1259-1265.e3, 2018

PubMed Abstract: Gene translation requires the correct selection of start codon AUG in mRNA. ATP-binding cassette subfamily F member 1 (ABCF1) plays a key role in the accuracy of start codon selection. However, the function of human ABCF1 is not clearly understood. Here, we solve the crystal structure of an ATP-bound wild-type human ABCF1 at 2.3-Å resolution. The comparative studies indicate that the structure is in a pre-activation intermediate conformation. This conformation is stabilized by the interaction between ATP and protein. Thus, we propose that this conformation is an important step in the activation of ABCF1. This study extends our understanding of ABC (ATP-binding cassette) protein activation at the molecular level.

PubMed: 30017566
DOI: 10.1016/j.str.2018.05.019

実験手法

X-RAY DIFFRACTION (2.288 Å)