5ZWE

Covalent bond formation between histidine of Vitamin D receptor (VDR) and a full agonist having a vinyl ketone group via conjugate addition reaction

5ZWE の概要

• エントリーDOI: 10.2210/pdb5zwe/pdb
• 分子名称: Vitamin D3 receptor, 13-meric peptide from DRIP205 NR2 BOX peptide, (6R)-6-[(1R,3aS,4E,7aR)-7a-methyl-4-[2-[(3R,5R)-4-methylidene-3,5-bis(oxidanyl)cyclohexylidene]ethylidene]-2,3,3a,5,6,7-hexahydro-1H-inden-1-yl]hept-1-en-3-one, ... (4 entities in total)
• 機能のキーワード: hormone covalent modifier transcription factor vitamind3 enone michael addition electrophile, transcription
• 由来する生物種: Rattus norvegicus (Rat); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 32564.51

構造登録者

Yoshizawa, M.,Itoh, T.,Anami, Y.,Kato, A.,Yoshimoto, N.,Yamamoto, K. (登録日: 2018-05-15, 公開日: 2018-07-18, 最終更新日: 2018-08-08)

• 主引用文献: Yoshizawa, M.,Itoh, T.,Hori, T.,Kato, A.,Anami, Y.,Yoshimoto, N.,Yamamoto, K.; Identification of the Histidine Residue in Vitamin D Receptor That Covalently Binds to Electrophilic Ligands; J. Med. Chem., 61:6339-6349, 2018; PubMed: 29936834; DOI: 10.1021/acs.jmedchem.8b00774

実験手法

X-RAY DIFFRACTION (2.72 Å)