5ZQF

Crystal structure of human topoisomerase II beta in complex with 5-iodouridine-containing-DNA in space group P3221

Summary for 5ZQF

DescriptorDNA topoisomerase 2-beta, DNA (5'-D(P*AP*GP*CP*CP*GP*AP*GP*C)-3'), DNA/RNA (5'-D(P*AP*GP*C)-R(P*(IU))-D(P*CP*GP*GP*C)-R(P*(IU))-3'), ... (4 entities in total)
Functional Keywordstype ii topoisomerase, cleavage complex, dna-gate, isomerase-dna complex, isomerase/dna
Biological sourceHomo sapiens (Human)
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Total number of polymer chains3
Total molecular weight97462.4
Authors
Chen, S.F.,Wang, Y.R.,Chan, N.L. (deposition date: 2018-04-18, release date: 2018-08-08, Last modification date: 2019-02-20)
Primary citation
Chen, S.F.,Huang, N.L.,Lin, J.H.,Wu, C.C.,Wang, Y.R.,Yu, Y.J.,Gilson, M.K.,Chan, N.L.
Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate.
Nat Commun, 9:3085-3085, 2018
PubMed: 30082834 (PDB entries with the same primary citation)
DOI: 10.1038/s41467-018-05406-y
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.873 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.24730 0.2% 0.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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More Biological unit images

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Molmil generated image of 5zqf
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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (5zqf.pdb1.gz [492.24 KB])