5ZNK
Crystal structure of a bacterial ProRS with ligands
Summary for 5ZNK
Entry DOI | 10.2210/pdb5znk/pdb |
Descriptor | Proline--tRNA ligase, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ... (6 entities in total) |
Functional Keywords | aminoacyl-trna synthetase, protein biosynthesis, inhibitor, ligase |
Biological source | Staphylococcus aureus |
Total number of polymer chains | 1 |
Total formula weight | 64922.64 |
Authors | |
Primary citation | Cheng, B.,Cai, Z.,Luo, Z.,Luo, S.,Luo, Z.,Cheng, Y.,Yu, Y.,Guo, J.,Ju, Y.,Gu, Q.,Xu, J.,Jiang, X.,Li, G.,Zhou, H. Structure-Guided Design of Halofuginone Derivatives as ATP-Aided Inhibitors Against Bacterial Prolyl-tRNA Synthetase. J.Med.Chem., 65:15840-15855, 2022 Cited by PubMed: 36394909DOI: 10.1021/acs.jmedchem.2c01496 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.07 Å) |
Structure validation
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