5ZNK

Crystal structure of a bacterial ProRS with ligands

5ZNK の概要

• エントリーDOI: 10.2210/pdb5znk/pdb
• 分子名称: Proline--tRNA ligase, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ... (6 entities in total)
• 機能のキーワード: aminoacyl-trna synthetase, protein biosynthesis, inhibitor, ligase
• 由来する生物種: Staphylococcus aureus
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 64922.64

構造登録者

Cheng, B.,Yu, Y.,Zhou, H. (登録日: 2018-04-09, 公開日: 2019-05-29, 最終更新日: 2023-11-29)

• 主引用文献: Cheng, B.,Cai, Z.,Luo, Z.,Luo, S.,Luo, Z.,Cheng, Y.,Yu, Y.,Guo, J.,Ju, Y.,Gu, Q.,Xu, J.,Jiang, X.,Li, G.,Zhou, H.; Structure-Guided Design of Halofuginone Derivatives as ATP-Aided Inhibitors Against Bacterial Prolyl-tRNA Synthetase.; J.Med.Chem., 65:15840-15855, 2022; PubMed: 36394909; DOI: 10.1021/acs.jmedchem.2c01496

実験手法

X-RAY DIFFRACTION (2.07 Å)