5ZNI

Plasmodium falciparum purine nucleoside phosphorylase in complex with mefloquine

5ZNI の概要

分子名称Purine nucleoside phosphorylase, PHOSPHATE ION, Mefloquine, ... (4 entities in total)
機能のキーワードtransferase, nucleoside phosphorylase
由来する生物種Plasmodium falciparum (malaria parasite P. falciparum)
ポリマー鎖数1
分子量合計27364.44
構造登録者
Chen, D.,Nordlund, P.,Dziekan, J.M. (登録日: 2018-04-09, 公開日: 2019-01-16)
主引用文献
Dziekan, J.M.,Yu, H.,Chen, D.,Dai, L.,Wirjanata, G.,Larsson, A.,Prabhu, N.,Sobota, R.M.,Bozdech, Z.,Nordlund, P.
Identifying purine nucleoside phosphorylase as the target of quinine using cellular thermal shift assay.
Sci Transl Med, 11:-, 2019
PubMed: 30602534 (主引用文献が同じPDBエントリー)
DOI: 10.1126/scitranslmed.aau3174
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2.3 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.25520 3.6% 3.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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