5ZLF

CRYSTAL STRUCTURE OF OCTAPRENYL PYROPHOSPHATE SYNTHASE FROM ESCHERICHIA COLI WITH ligand BPH-629

Summary for 5ZLF

• Entry DOI: 10.2210/pdb5zlf/pdb
• Descriptor: Octaprenyl diphosphate synthase, [2-(3-DIBENZOFURAN-4-YL-PHENYL)-1-HYDROXY-1-PHOSPHONO-ETHYL]-PHOSPHONIC ACID, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: prenyltransferase, site-directed mutagenesis, product chain length, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Escherichia coli K-12
• Total number of polymer chains: 4
• Total formula weight: 141496.43

Authors

Han, X.,Liu, W.D.,Zheng, Y.Y.,Ko, T.P.,Chen, C.C.,Guo, R.T. (deposition date: 2018-03-27, release date: 2019-03-27, Last modification date: 2023-11-22)

• Primary citation: Malwal, S.R.,Chen, L.,Hicks, H.,Qu, F.,Liu, W.,Shillo, A.,Law, W.X.,Zhang, J.,Chandnani, N.,Han, X.,Zheng, Y.,Chen, C.C.,Guo, R.T.,AbdelKhalek, A.,Seleem, M.N.,Oldfield, E.; Discovery of Lipophilic Bisphosphonates That Target Bacterial Cell Wall and Quinone Biosynthesis.; J.Med.Chem., 62:2564-2581, 2019; PubMed: 30730737; DOI: 10.1021/acs.jmedchem.8b01878

Experimental method

X-RAY DIFFRACTION (2.845 Å)