Crystal structure of the human platelet-activating factor receptor in complex with ABT-491

Summary for 5ZKQ

DescriptorPlatelet-activating factor receptor,Endolysin,Endolysin,Platelet-activating factor receptor, 4-ethynyl-3-{3-fluoro-4-[(2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)methyl]benzene-1-carbonyl}-N,N-dimethyl-1H-indole-1-carboxamide, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ... (6 entities in total)
Functional Keywordsg protein-coupled receptor, platelet-activating factor receptor, complex, signaling protein
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight104417.07
Cao, C.,Zhao, Q.,Zhang, X.C.,Wu, B. (deposition date: 2018-03-25, release date: 2018-06-20)
Primary citation
Cao, C.,Tan, Q.,Xu, C.,He, L.,Yang, L.,Zhou, Y.,Zhou, Y.,Qiao, A.,Lu, M.,Yi, C.,Han, G.W.,Wang, X.,Li, X.,Yang, H.,Rao, Z.,Jiang, H.,Zhao, Y.,Liu, J.,Stevens, R.C.,Zhao, Q.,Zhang, X.C.,Wu, B.
Structural basis for signal recognition and transduction by platelet-activating-factor receptor.
Nat. Struct. Mol. Biol., 25:488-495, 2018
PubMed: 29808000 (PDB entries with the same primary citation)
DOI: 10.1038/s41594-018-0068-y
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.257403.7%3.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution