5ZKQ

Crystal structure of the human platelet-activating factor receptor in complex with ABT-491

Summary for 5ZKQ

• Entry DOI: 10.2210/pdb5zkq/pdb
• Descriptor: Platelet-activating factor receptor,Endolysin,Endolysin,Platelet-activating factor receptor, 4-ethynyl-3-{3-fluoro-4-[(2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)methyl]benzene-1-carbonyl}-N,N-dimethyl-1H-indole-1-carboxamide, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ... (6 entities in total)
• Functional Keywords: g protein-coupled receptor, platelet-activating factor receptor, complex, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 104417.07

Authors

Cao, C.,Zhao, Q.,Zhang, X.C.,Wu, B. (deposition date: 2018-03-25, release date: 2018-06-20, Last modification date: 2023-11-22)

• Primary citation: Cao, C.,Tan, Q.,Xu, C.,He, L.,Yang, L.,Zhou, Y.,Zhou, Y.,Qiao, A.,Lu, M.,Yi, C.,Han, G.W.,Wang, X.,Li, X.,Yang, H.,Rao, Z.,Jiang, H.,Zhao, Y.,Liu, J.,Stevens, R.C.,Zhao, Q.,Zhang, X.C.,Wu, B.; Structural basis for signal recognition and transduction by platelet-activating-factor receptor.; Nat. Struct. Mol. Biol., 25:488-495, 2018; PubMed: 29808000; DOI: 10.1038/s41594-018-0068-y

Experimental method

X-RAY DIFFRACTION (2.9 Å)